发明名称 |
MIXED-BACKBONE OLIGONUCLEOTIDES CONTAINING POPS BLOCKS TO OBTAIN REDUCED PHOSPHOROTHIOATE CONTENT |
摘要 |
Mixed-backbone oligonucleotides POPS blocks have been designed and studied for their target affinity, nuclease stability in vitro and in vivo, Rnase H-activation properties, and their effect on phosphorothioate-related prolongation of partial thromboplastin time, in an effort to have agents with improved antisense activity with reduced phosphorothioate content.
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申请公布号 |
WO9950409(A1) |
申请公布日期 |
1999.10.07 |
申请号 |
WO1999US07276 |
申请日期 |
1999.04.01 |
申请人 |
HYBRIDON, INC. |
发明人 |
ZHOU, WEN, QIANG;AGRAWAL, SUDHIR |
分类号 |
C12N15/113;(IPC1-7):C12N15/11;C07H21/00 |
主分类号 |
C12N15/113 |
代理机构 |
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