发明名称 |
Method for combined conditioning and chemoselection in a single cycle |
摘要 |
A method of radiation-free hematopoietic stem cell (HSC) transplantation comprises administering to a mammalian subject one or two doses of 2 to 10 mg/kg body weight of a purine base analog, such as 6TG as a pre-conditioning step. The method further comprises engrafting into the subject hypoxanthine-guanine phosphoribosyltransferase (HPRT)-deficient donor HSCs within 48 to 72 hours of the pre-conditioning step; and administering to the subject about 1 to 5 mg/kg of the purine base analog every two to four days for two to eight weeks following the engrafting step. The method is performed in the absence of pre-conditioning via radiation. The subject is therefore not treated with myeloablative radiation in preparation for transplantation, and thus the subject is free of myeloablative radiation-induced toxicity. |
申请公布号 |
AU2012245269(B2) |
申请公布日期 |
2016.09.29 |
申请号 |
AU20120245269 |
申请日期 |
2012.04.20 |
申请人 |
The Regents of The University of California |
发明人 |
Kasahara, Noriyuki;Schiestl, Robert H.;Hacke, Katrin;Szakmary, Akos;Crooks, Gay M. |
分类号 |
A61K35/14;A61K31/52;A61K35/28;A61P37/06;C12N5/071 |
主分类号 |
A61K35/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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