发明名称 |
FIBRIN COMPOSITION, METHOD AND WOUND ARTICLES |
摘要 |
A method of forming a fibrin hydrogel composition is described. The method comprises forming an aqueous solution comprising fibrinogen, fibrin-forming enzyme, and a fibrin hydrogel forming salt. The fibrin hydrogel forming salt concentration is greater than or equal to the threshold concentration to form a fibrin hydrogel. The method further comprises reducing the salt concentration below the threshold concentration to form a fibrin hydrogel. In some embodiments, the aqueous solution further comprises a plasticizer. A fibrin composition is also described comprising a fibrin hydrogel having a fibrin concentration ranging from 0.1 to 10 wt-%; and a fibrin hydrogel forming salt. The fibrin hydrogel forming salt has a concentration less than a threshold concentration to form the fibrin hydrogel. The fibrin hydrogel or dehydrated fibrin hydrogel can be in various physical forms such a sheet, foam, or plurality of pieces. Also described are methods of forming a fibrin article, wound dressings and a method of treatment of a wound. |
申请公布号 |
WO2016160541(A1) |
申请公布日期 |
2016.10.06 |
申请号 |
WO2016US24141 |
申请日期 |
2016.03.25 |
申请人 |
3M INNOVATIVE PROPERTIES COMPANY |
发明人 |
BJORK, Jason W.;YOUNG, Alexi J.;BEEN, Raha A.;NINKOVIC, Jana;BAKER, Bryan A. |
分类号 |
A61L24/10 |
主分类号 |
A61L24/10 |
代理机构 |
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地址 |
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