Multiplex fiber optic biosensor and detection method by using the same

摘要

A multiplex fiber optic biosensor including an optical fiber, a plurality of noble metal nanoparticle layers, a plurality of light sources and a light source function generator is disclosed. The optical fiber includes a plurality of sensing regions which are unclad regions of the optical fiber so that the fiber core is exposed, wherein the noble metal nanoparticle layers are set in each sensing regions. The light sources emit light with different wavelengths, and the noble metal nanoparticle layers absorb the lights with different wavelengths, respectively. The light sources emit the lights in different timing sequences or different carrier frequencies, wherein when the lights propagate along the optical fiber in accordance with the different timing sequences or the different carrier frequencies, a detection unit detects particle plasmon resonance signals produced by interactions between the different noble metal nanoparticle layers and the corresponding analytes.

主权项

1. A multiplex fiber optic biosensor, comprising:
an optical fiber including a plurality of sensing regions, wherein the sensing regions are unclad regions of the optical fiber so that a fiber core of the optical fiber is exposed; a plurality of noble metal nanoparticle layers being set in the sensing regions; a plurality of light sources designed to emit lights with different wavelengths, and the noble metal nanoparticle layers absorbing the lights with different wavelengths, respectively, wherein each of the plurality of light sources corresponds to one of the sensing regions; and a light source function generator designed to generate a function for enabling the plurality of light sources continuously emitting the lights with different carrier frequencies in accordance with the function; wherein, when the lights propagate along the optical fiber in accordance with the different carrier frequencies, only one detector is used to detect particle plasmon resonance signals produced by interactions between the noble metal nanoparticle layers and corresponding analytes, wherein the light source function generator is electrically coupled to the detector and transmits the function to the detector, so as to analyze the particle plasmon resonance signals.