ANTIBODIES TO HUMAN GDF8

摘要

The present invention provides isolated human or humanized antibodies or antigen-binding fragments thereof which specifically bind to Growth and Differentiation Factor-8 (GDF8) and block GDF8 activity. The antibodies and antibody fragments of the present invention may be used in therapeutic methods for treating conditions or disorders which are ameliorated or improved by inhibition of GDF8.

主权项

1. An isolated human antibody or antigen-binding fragment thereof that specifically binds to, or blocks the biological activity of wild-type mature human GDF8 comprising SEQ ID NO:340, but does not bind to, or block the biological activity of a chimeric GDF8/TGFβ1 construct having amino acids 48-72 of mature human GDF8 replaced with the corresponding amino acid sequence of TGFβ1, wherein the isolated human antibody or antigen-binding fragment comprises: (a) heavy chain CDRs (HCDR1, HCDR2 and HCDR3) from a heavy chain variable region having an amino acid sequence of SEQ ID NO: 360; and (b) light chain CDRs (LCDR1, LCDR2 and LCDR3) from a light chain variable region having an amino acid sequence of SEQ ID NO: 368.