| 摘要 |
Nucleotide sequences of D2-2 genes (human D2-2 and D2-2 homologs of other species), and amino acid sequences of their encoded proteins, as well as derivatives (e.g., fragments) and analogs thereof are disclosed. Nucleic acids hybridizable to or complementary to the nucleotide sequences are also disclosed. D2-2 is a gene expressed at high levels in glioblastoma multiforme tissue as well as certain other forms of tumors and cancers. Therapeutic and diagnostic methods and compositions based on D2-2 proteins fragments and analogs, anti-D2-2 antibodies and nucleic acids for treatment of disorders of overproliferation (e.g., tumors, cancer and hyperproliferative disorders are disclosed. |
