发明名称 Prodrugs for antimicrobial amidines
摘要 A methods of treating an infection comprises administering a therapeutically effective amount of a compound described by the Formula (I):wherein:X may be O, S, or NR' wherein R' is H or loweralkyl;R1 and R2 may be independently selected from the group consisting of H, loweralkyl, oxyalkyl, alkoxyalkyl, cycloalkyl, aryl, hydroxyalkyl, aminoalkyl, and alkylaminoalkyl;R3 and R4 are each independently selected from the group consisting of H, loweralkyl, halogen, oxyalkyl, oxyaryl, and oxyarylalkyl;R5 is represented by a formula selected from the group consisting of: wherein:X1, X2, and X3 are independently selected from O and S; and R6 and R7 are independently selected from the group consisting of loweralkyl, aryl, alkylaryl, oxyaryl, an ester-containing substituent, and oxyalkyl; or a pharmaceutically acceptable salt thereof.
申请公布号 US6486200(B1) 申请公布日期 2002.11.26
申请号 US20000612138 申请日期 2000.07.07
申请人 THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL;GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. 发明人 BOYKIN DAVID W.;RAHMATHULLAH M. SYED;TIDWELL RICHARD R.;HALL JAMES E.
分类号 C07D307/52;A61K31/341;A61K31/357;A61K47/48;A61P31/00;A61P31/04;A61P31/06;C07D307/54;C07D407/12;C07D407/14;(IPC1-7):A61K31/357;C07D317/14 主分类号 C07D307/52
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