Methods for detecting parenchymal plaques in vivo

摘要

Methods for detecting parenchymal plaque deposits in the brain of a living mammal are described that include administering a polyamine modified, labeled polypeptide having specific binding affinity for the extracellular deposit, to the living mammal. Isolated beta-amyloid peptides that are polyamine modified and labeled with a radioisotope or contrast agent also are described.