发明名称 |
C10-SUBSTITUTED CAMPTOTHECIN ANALOGS |
摘要 |
The novel C10-modified camptothecin analogs, and pharmaceutically-acceptable salts thereof, of the present invention: (i) possess potent antitumor activity (i.e., in nanomolar or subnanomolar concentrations) for inhibiting the growth of human and animal tumor cells in vitro; (ii) are potent inhibition of Topoisomerase I; (iii) lack of susceptibility to MDR/MRP drug resistance; (iv) require no metabolic drug activation: (v) lack glucuronidation of the A-ring or B-ring; (vi) reduce drug-binding affinity to plasma proteins; (vii) maintain lactone stability; (viii) maintain drug potency; and (ix) possess a low molecular weight (e.g., MW<600).
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申请公布号 |
CA2700904(A1) |
申请公布日期 |
2009.04.23 |
申请号 |
CA20072700904 |
申请日期 |
2007.10.16 |
申请人 |
BIONUMERIK PHARMACEUTICALS, INC. |
发明人 |
NARKUNAN, KESAVARAM;CHEN, XINGHAI;KOCHAT, HARRY;HAUSHEER, FREDERICK |
分类号 |
A01N43/42;A61K31/44 |
主分类号 |
A01N43/42 |
代理机构 |
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