| 主权项 |
1. A method for discriminating between breast cancer and benign breast disease in a biological sample from a patient, the method comprising the following steps:
a) obtaining the biological sample comprising a biological material from the patient, b) contacting the biological material from the biological sample with at least one specific reagent for at least one target gene and no more than 28 specific reagents for 28 target genes comprising the full-length nucleic acid sequences set forth in SEQ ID NOS: 1 to 44, wherein the at least one reagent is specific for at least one target gene comprising the full-length nucleic acid sequence set forth in SEQ ID NOS: 1 to 6, c) measuring the expression level of the at least one target gene to obtain an expression profile for the patient, and d) performing clustering analysis of the expression profile of the patient with expression profiles of the at least one target gene from patients previously clinically classified as having breast cancer and expression profiles of the at least one target gene from patients previously clinically classified as having benign breast disease, wherein:
if the expression profile of the patient is clustered with the expression profiles from patients previously clinically classified as having breast cancer, then the patient is diagnosed to have breast cancer, andif the expression profile of the patient is clustered with the expression profiles from patients previously clinically classified as having benign breast disease, then the patient is diagnosed to have a benign breast disease. |
