发明名称 |
PHARMACEUTICAL COMPOSITION IN WHICH SOLUBILITY OF PARTIALLY SOLUBLE TRICYCLIC DERIVATIVE IS IMPROVED |
摘要 |
The present invention relates to a pharmaceutical composition comprising a phospholipid, cholesterol, an ionic lipid, and nanoparticles comprising a tricyclic derivative, wherein the solubility of the tricyclic derivative is improved. According to the present invention, it is possible to solubilize a partially soluble tricyclic derivative in a high concentration even without using a solubilization aid harmful to the human body, to maintain improved solubility even if water is added for the use as an injection, and to show stability even if stored for a long time, by preparing lipid nanoparticles. Therefore, the lipid nanoparticles of the present invention can be used for preparing a pharmaceutical preparation containing a partially soluble tricyclic derivative as an active ingredient. |
申请公布号 |
EP2586430(B1) |
申请公布日期 |
2016.11.02 |
申请号 |
EP20110798395 |
申请日期 |
2011.06.23 |
申请人 |
JEIL PHARMACEUTICAL CO., LTD. |
发明人 |
KIM, MYUNG-HWA;CHUN, KWANG-WOO;YE, IN-HAE;CHOI, JONG-HEE |
分类号 |
A61K31/01;A61K9/00;A61K9/51;A61K31/66 |
主分类号 |
A61K31/01 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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