A CONTROLLED RELEASE SYSTEM FOR PULMONARY DELIVERY OF SURFACTANT PROTEIN D

摘要

The present invention provides a controlled release system comprising surfactant protein D (SPD) and a carrier suitable for controlled release that can be polylactic-co-glycolic acid (PLGA); the system may be in the form of a nanoparticle. The present invention further provides a pharmaceutical composition comprising the system and a pharmaceutically acceptable carrier, uses thereof, and methods of treatment of a disease, disorder or condition associated with a decreased level of SPD in a subject, or for pulmonary delivery of SPD, comprising administering the pharmaceutical composition of the invention to a subject in need thereof.