Compounds of formula [1,1'-biphenyl]-2-carboxylic acid, 2'-[[[(substituted)phenyl]-(substituted)amino]carbonyl]-, pharmaceutical compositions comprising the compounds, and a process for preparing the compounds.

摘要

The present invention provides various novel diphenic acid monoamide compounds of the formula
<Chemistry id="chema01" num="0001"><Image id="ia01" he="31" wi="58" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>Also provided are novel pharmaceutical compositions comprising . the compounds and novel methods for synthesising the compounds. The novel diphenic acid monoamides of the present invention areleukotriene antagonists, 5-lipoxygenase inhibitors, and mediator release inhibitors providing activity useful for treating asthma, allergies, cardiovascular diseases, migraines, and immunoinflammatory conditions.