PEPTIDES SELECTIVELY LETHAL TO MALIGNANT AND TRANSFORMED MAMMALIAN CELLS
摘要
<p>The present invention provides peptides corresponding to all or a portion of amino acid residues 12-26 of human p53 protein, which peptides are lethal to malignant or transformed cells when fused to a membrane-penetrating leader sequence. The subject peptides are thus useful in treating neoplastic disease in an animal, preferably a human. Also provided are pharmaceutical compositions comprising the subject peptides admixed with a pharmaceutical acceptable carrier. Methods of treating neoplastic disease in a patient by administering a subject peptide fused at its carboxy terminal end to a membranepenetrating leader sequence are also provided. The present invention also provides replication incompetent Adenovirus (AdV) vectors comprising a promoter sequence operably linked to a nucleotide sequence encoding a subject peptide. Methods of selectively killing cancer cells in a subject by administering a therapeutically effective amount of a subject AdV vector are also provided by the present invention.</p>
申请公布号
WO2004081030(A2)
申请公布日期
2004.09.23
申请号
WO2004US00684
申请日期
2004.01.13
申请人
THE RESEARCH FOUNDATION OF THE STATE UNIVERSITY OFNEW YORK;MICHL, JOSEF;KOEHNKE, JESKO;PINCUS, MATTHEW, R.