POLYMER CONJUGATES OF CYTOKINES, CHEMOKINES, GROWTH FACTORS, POLYPEPTIDE HORMONES AND ANTAGONISTS THEREOF

摘要

Methods are provided for the synthesis in vitro of polymer conjugates of cytokines, which selectively conjugates to amino-terminal amino acid which is disposed at a distance from receptor-binding regions of cytokines, chemokines, growth factors and polypeptide hormones, as well as to agonistic and antagonistic analogs thereof. The pharmaceutical compositions produced by said method comprising conjugates and use thereof for treatment of various tumors and infection autoimmune and genetic diseases.