| 摘要 |
Applicants have discovered that a particular bacteriocin from the vaginal strain of Lactobacillus rhamnosus, lactocin (160), possesses a particularly advantageous activity against microorganisms associated with vaginal infections, and more specifically those associated with Bacterial Vaginosis (BV). Specifically, this compound is an effective and non-cytotoxic antibacterial agent that provides the basis for formulations MW for the improved prophylaxis and treatment of vaginal infections, and attendant reduction in the acquisition and proliferation of HIV. Applicants have isolated and purified the antimicrobial peptide lactocin (160) from a vaginal strain of L. rhamnosus. The peptide shows antibacterial activity in an agar-well bioassay against the major BV-associated bacteria, G. vaginalis and anaerobes (P bivia and Peptostreptococcus spp.) and does not inhibit the growth of lactobacilli species which are endogenous to a healthy vaginal environment.
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