发明名称 Imidazole derivatives
摘要 The present invention relates to imidazole derivatives of the general formula wherein R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>3 </SUP>and R<SUP>4 </SUP>are as defined hereinabove. This invention also relates to the compound's pharmaceutically acceptable salt and processes for the preparation thereof. These compounds can be used for the manufacture of pharmaceutical compositions for the treatment and prevention of mGluR5 receptor mediated disorders. These compounds are useful, inter alia, in the treatment or prevention of acute and/or chronic neurological disorders such as psychosis, epilepsy, schizophrenia, Alzheimer's disease, cognitive disorders and memory deficit disorders, as well as chronic and acute pain.
申请公布号 US7091222(B2) 申请公布日期 2006.08.15
申请号 US20040874948 申请日期 2004.06.23
申请人 HOFFMANN-LA ROCHE INC. 发明人 BUETTELMANN BERND;CECCARELLI SIMONA MARIA;JAESCHKE GEORG;KOLCZEWSKI SABINE;PORTER RICHARD HUGH PHILIP;VIEIRA ERIC
分类号 A61K31/4439;A61K31/4178;A61P25/00;A61P25/22;C07D401/06 主分类号 A61K31/4439
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