ルイス酸触媒を使用してバッカチン誘導体からタキソイドを調製するための方法

摘要

The present invention relates to a process of preparing a taxoid (X) by reacting a protected baccatin derivative (B) with a &bgr;-lactam (C) in the presence of one or more Lewis acids and a base agent. The present invention also relates to a process of preparing the protected baccatin derivative (B) from a baccatin derivative (A) comprising a protection reaction catalyzed by one or more Lewis acids with an optional base agent.