发明名称 |
Application of mRNA for use as a therapeutic against tumour diseases |
摘要 |
The present invention relates to a pharmaceutical composition comprising at least one mRNA comprising at least one coding region for at least one antigen from a tumor, in combination with an aqueous solvent and preferably a cytokine, e.g. GM-CSF, and a process for the preparation of the pharmaceutical composition. The pharmaceutical composition according to the invention is used in particular for therapy and/or prophylaxis against cancer. |
申请公布号 |
US9433670(B2) |
申请公布日期 |
2016.09.06 |
申请号 |
US201514965551 |
申请日期 |
2015.12.10 |
申请人 |
CureVac AG |
发明人 |
Hoerr Ingmar;Von Der Mülbe Florian;Pascolo Steve |
分类号 |
A61K39/00;A61K38/19;A61K9/00;A61K48/00 |
主分类号 |
A61K39/00 |
代理机构 |
Parker Highlander PLLC |
代理人 |
Parker Highlander PLLC |
主权项 |
1. A method of stimulating an antitumor immune response in a subject comprising administering an effective amount of a cell-free composition comprising mRNA encoding an MAGE antigen to a subject in need thereof, thereby stimulating a T-cell mediated cytotoxic anticancer immune response in the subject. |
地址 |
Tübingen DE |