发明名称 |
Compositions containing broccoli seeds for treatment or preventing prostate cancer |
摘要 |
The invention relates to a composition for treating or preventing prostate cancer or the recurrence thereof; including a non-aqueous extract of non-germinated broccoli seeds of the Brassica Oleracea Italica variety that are rich in sulforaphane. The extract is encapsulated by a compound selected from the group including acacia gum, maltodextrin, and the mixture thereof, and said composition can be provided in the form of a capsule, tablet, sugarcoated tablet, or film-coated tablet, and is orally administered one to three times a day at a daily dose of 2 to 200 mg. |
申请公布号 |
US9433654(B2) |
申请公布日期 |
2016.09.06 |
申请号 |
US201214128874 |
申请日期 |
2012.05.29 |
申请人 |
Sojasun Technologies |
发明人 |
Efstathiou Theo;Plu Nicolas |
分类号 |
A61K36/31;A23L1/30;A61K9/28 |
主分类号 |
A61K36/31 |
代理机构 |
Thomas|Horstemeyer, LLP |
代理人 |
Thomas|Horstemeyer, LLP |
主权项 |
1. A method for obtaining a sulforaphane-containing composition for the treatment of prostate cancer or its recurrence comprising:
a. mechanically cold pressing non-sprouted broccoli seeds of the Brassica Oleracea Italica variety to obtain a partially delipidated cake containing glucoraphanin; b. obtaining a hydrolysate by enzymatically hydrolyzing the partially delipidated cake to hydrolyze the glucoraphanin into sulforaphane; c. adding acetone to the hydrolysate to reduce lipid content and erucic acid content of the hydrolysate to a concentration below 5% by weight; d. filtering the hydrolysate to recover a filtrate with a low content of lipids and a concentration below 5% by weight of erucic acid; e. evaporating the acetone of the filtrate to recover an aqueous phase; f. adding ethyl acetate to the aqueous phase to recover a phase containing the ethyl acetate and sulforaphane; g. evaporating the ethyl acetate contained in the phase containing the ethyl acetate and sulforaphane to obtain a non-aqueous extract containing at least 30% by weight of sulforaphane; h. drying the non-aqueous extract on a polysaccharide support selected from the group consisting of: acacia gum, maltodextrin, and their mixture, to obtain a powder; i. incorporating the powder in a polysaccharide matrix selected from the group consisting of: acacia gum, maltodextrin, and the mixture thereof, to obtain an encapsulated powder containing at least 10% by weight of sulforaphane j. incorporating the encapsulated powder within a pharmaceutical form selected from the group consisting of: a capsule, a tablet, a coated pill, and a film-coated tablet; said method being performed without a step of aqueous extraction between the step g and the step h. |
地址 |
Noyal sur Vilaine FR |