发明名称 |
Methods of inhibiting growth of a neoplastic cell |
摘要 |
Disclosed are methods of preparing and using placentally-derived stem cells and compositions useful for the treatment of cancer. Said stem cells and compositions function through inducing a “guided differentiation” program in cancer cells, thereby reducing malignancy. Further extension of the invention pertains to augmenting ability of administered cells to induce differentiation through the co-administration of known differentiation inducing agents. Within the context of this disclosure, methods for inducing host responses to cancer are also described. |
申请公布号 |
US9433646(B2) |
申请公布日期 |
2016.09.06 |
申请号 |
US201213688864 |
申请日期 |
2012.11.29 |
申请人 |
XON CELLS, INC. |
发明人 |
Ichim Thomas E. |
分类号 |
A61K35/54;A61P35/00;G01N30/02;A61K35/50;A61K35/44;C12N5/073 |
主分类号 |
A61K35/54 |
代理机构 |
Knobbe, Martens, Olson & Bear LLP |
代理人 |
Knobbe, Martens, Olson & Bear LLP |
主权项 |
1. A method of inhibiting growth of a neoplastic cell, the method comprising:
(a) providing a cell free-placental extract made by the process comprising: (i) obtaining human placenta; (ii) homogenizing the obtained human placenta by digesting the obtained human placenta with a collagenase and a heparitinase, wherein the heparitinase digestion is at a neutral pH, the homogenization resulting in a homogenate; (iii) centrifuging said homogenate to produce a supernatant free of cellular debris; and (iv) purifying the supernatant to obtain cell free-placental extract comprising a cell differentiation-inducing fraction having a molecular weight in the range from about 10 Daltons to about 10,000 Daltons (b) directly administering said cell free-placental extract to the neoplastic cell which is selected from the group consisting of a leukemia cell, and a prostate cancer cell, thereby inhibiting growth of the neoplastic cell. |
地址 |
Germantown MD US |