Composition for prevention or treatment of cancer comprising N-methylenenaphtho[2,1-<i>b</i>]furan-2-carbohydrazide derivatives as an active ingredient

摘要

The present invention relates to ethyl(2-methyl-3{(E)-[(naphtho[2,1-b]furan-2-ylcarbonyl)hydrazono]methyl}-1H-indole-1-yl)acetate, the novel mitosis inhibitor. The said ethyl(2-methyl-3{(E)-[(naphtho[2,1-b]furan-2-ylcarbonyl)hydrazono]methyl}-1H-indole-1-yl)acetate not only induces apoptosis by inhibiting tubulin polymerization in the course of mitosis but also displays an excellent anticancer effect in the multi-drug resistant cancer cells, so that it can be effectively used for the treatment of cell proliferative disease including various cancers.

主权项

1. A method of treating cancer, comprising administering a pharmaceutically effective dose of a compound represented by the below formula 1 or a pharmaceutically acceptable salt thereof as an active ingredient to a subject having cancer: wherein R1 is wherein R2 is methyl, R3 is methyl, allyl, cyanomethyl or —CH2(C═O)OCH2CH3, and R4 is nitro, 4-bromophenyl, 2,3-dichlorophenyl, 4-nitrophenyl or 4-methyl-3-nitrophenyl.