| 主权项 |
1. A method for enhancing cell survival and proliferation, the method comprising:
(a) generating isolated cells comprising stem cells, progenitor cells, or differentiated cells therefrom; and (b) contacting the isolated cells with an amount of a compound having formula (I) sufficient to improve survival of the cells by at least 2-fold compared to the absence of the compound:wherein,
L2 is substituted or unsubstituted C1-C10 alkylene; and y is an integer from 0 to 3; z is an integer from 0 to 5; X is —N═, —CH═ or —CR5═; R1 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R3, R4 and R5 are independently —CN, —S(O)nR6, —NR7R8, —C(O)R9, —NR10—C(O)R11, —NR—C(O)—OR13, —C(O)NR14R15, —NR16S(O)2R17, —OR18, —S(O)2N(R19)2, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, wherein n is an integer from 0 to 2, wherein if z is greater than 1, two R3 moieties are optionally joined together to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18 and R19 are independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; or a racemate, diastereomer, tautomer, or a geometric isomer thereof, or a pharmaceutically acceptable salt thereof. |
