NORRIN REGULATION OF JUNCTION PROTEINS AND USE THEREOF TO TREAT EPITHELIAL OR ENDOTHELIAL MEMBRANE LEAKAGE INDUCED EDEMA

摘要

A method of tightening inter-cellular junctions in endothelial or epithelial cells includes exposing the endothelial or epithelial cells cells to norrin. Upon sufficient contact time, for norrin to selectively up- regulate gene expression of Cadherin or claudin-5 in the endothelial or epithelial cells, the inter-cellular junctions are tightened.