Processes for the preparation of substituted isoxazoles and 2-isoxazolines

摘要

Provided are compounds, processes and synthetic intermediates useful for the preparation of compounds of the formula I and IX wherein R¹ is selected from the group consisting of hydrogen, trihalomethyl, C₁-C₆ alkyl and substituted or unsubstituted phenyl; Y is a group of the formula wherein R² is selected from the group consisting of C₁-C₆ alkyl, C₁-C₆ alkanoylamino and amino; and R⁵ is selected from the group consisting of hydrogen, amino, halogen, hydroxyl, nitro, C₁-C₆ alkyl, C₁-C₆ alkoxy, carboxy, C₁-C₆ trihaloalkyl, cyano, phosphonato, and hydroxyalkyl; and Z is selected from the group consisting of substituted and unsubstituted aryl. Also provided are certain N-acylated analogs of compounds of the formula I and IX, and processes for their preparation.