BENZAZOLE DERIVATIVES AND THEIR USE AS JNK MODULATORS

摘要

The present invention is related to benzazole derivatives according to formula (I) wherein G is a pyrimidinyl group, substituted by at least one substituents; Ris hydrogen or C-C-alkyl, optionally substituted with halogen; Ris hydrogen or C-C-alkyl, for use as a pharmaceutically active compound and also to pharmaceutically preparative formulations comprising such benzazole derivatives. Said benzazoles derivatives are efficient modulators of the JNK pathway, they are in particular efficient and selective inhibitors of JNK2 and/or 3.