MUTANT PHOSPHORIBOZYL PYROPHOSPHATE SYNTHETASE, DNA FRAGMENT, BACTERIA OF GENUS ESCHERICHIA AS L-HISTIDINE AND METHOD FOR PRODUCTION OF L-HISTIDINE

摘要

FIELD: biotechnology. ^ SUBSTANCE: method for production L-histidine includes culturing of Escherichia genus bacteria, containing DNA fragment encoding of mutant bacterial phosphoribozyl pyrophosphate synthetase (FRPP-synthetase), and collection of produced and accumulated L-histidine from cultural liquid, wherein in mutant FRPP-synthetase L-amino acid residue, corresponding to 115-position of amino acid sequence in natural FRPP-synthetase from Escherichia coli is replaced by serine residue. ^ EFFECT: high effective method for production of L-histidine. ^ 11 cl, 1 tbl, 2 ex