| 发明名称 |
Antibodies to hepatitis C virus asialoglycoproteins |
| 摘要 |
Two Hepatitis C Virus envelope proteins (E1 and E2) are expressed without sialylation. Recombinant expression of these proteins in lower eukaryotes, or in mammalian cells in which terminal glycosylation is blocked, results in recombinant proteins which are more similar to native HCV glycoproteins. When isolated by GNA lectin affinity, the E1 and E2 proteins aggregate into virus-like particles.
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| 申请公布号 |
US7105303(B2) |
申请公布日期 |
2006.09.12 |
| 申请号 |
US20010929782 |
申请日期 |
2001.08.13 |
| 申请人 |
NOVARTIS VACCINES AND DIAGNOSTICS, INC. |
发明人 |
RALSTON ROBERT O.;MARCUS FRANK;THUDIUM KENT B.;GERVASE BARBARA A.;HALL JOHN A.;BERGER KIM M.;CHOO QUI-LIM;HOUGHTON MICHAEL;KUO GEORGE |
| 分类号 |
G01N33/53;G01N33/576;A61K35/16;A61K38/00;A61K38/10;A61K39/00;A61K39/29;A61P1/16;A61P31/12;C07K14/18;C12N1/19;C12N5/10;C12N15/09;C12N15/51;C12P21/02;C12P21/04 |
主分类号 |
G01N33/53 |
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