ADAMANTYL ACETAMIDES AS 11-BETA HYDROXYSTEROID DEHYDROGENASE INHIBITORS

摘要

The invention relates to adamantyl acetamides of formula (I) the N-oxide forms thereof, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein n represents an integer being 1 or 2; Rand R, each independently represents hydrogen Calkyl; or Rand Rtaken together with the carbon atom with which they are attached form a Ccycloalkyl; Rrepresents optionally substituted adamantyl of formula (a) or (b); Q represents optionally substituted phenyl, benzothiophyl, or pyridinyl, L represents Calkyl. Besides, the relation relates to a pharmaceutical composition, comprising a pharmaceutically acceptable carrier and, as an active ingredient, an effective beta-HSD1 inhibitory amount of a compound, a process of preparing a pharmaceutical composition and use of a compound in the manufacture of a medicament for treating of visceral obesity, diabetes type 2, hyperlipidimia and hyperphagia.