发明名称 |
METHODS FOR ENHANCING THE THERAPEUTIC EFFICACY OF TOPOISOMERASE INHIBITORS |
摘要 |
Disclosed are methods and compositions useful in identifying an E3 ubiquitin ligase inhibitor and modulating cell growth, comprising contacting a cell with an effective amount of an inhibitor of an E3 ubiquitin ligase, and contacting the cell with an effective amount of a topoisomerase inhibitor, wherein the treatment with the E3 ubiquitin ligase inhibitor and topoisomerase inhibitor modulates cell growth in comparison to a cell treated with the topoisomerase inhibitor alone. The present invention further provides methods for identifying and making an E3 ubiquitin ligase inhibitor. |
申请公布号 |
EP2120940(A2) |
申请公布日期 |
2009.11.25 |
申请号 |
EP20080702654 |
申请日期 |
2008.01.16 |
申请人 |
PROTELOGIECS, LTD. |
发明人 |
EREZ, OMRI;ALCHANATI, IRIS;NAKACHE, PHILIPPE |
分类号 |
A61K31/4406;A61K31/4745;A61K31/7048;A61P35/00;G01N33/574 |
主分类号 |
A61K31/4406 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|