Compositions for Liquidation of Tumors

摘要

This invention relates to compositions and methods for immunotherapy of cancer. Specifically, a method of cancer immunotherapy is described which results in the systemic liquidation of both solid and metastatic tumors whereever they reside in the body. The compositions include activated allogeneic Th1 cells that when administered appropriately lead to liquidation of tumors. The method includes administering priming doses of the therapeutic composition, ablation of a selected tumor lesion along with intratumoral injection of the composition and then infusion of the therapeutic composition. These steps enable the systemic liquidation of tumors secondary to immune cell infiltration and leads to immune-mediated tumor eradication.

主权项

1. A therapeutic composition comprising at least three components, the three components comprising:
at least one foreign antigen wherein the foreign antigen is an alloantigen expressed by T-cells, wherein the T-cells are inactivated T-cells; at least one Type I inflammatory cytokine wherein the cytokine is selected from the cytokines produced by activated T-cells; and at least one effector molecule capable of causing maturation of dendritic cells wherein the effector molecule is selected from the effector molecules expressed in activated T-cells, wherein the three components are suspended in formulation buffer, the composition enables tumor eradication in a patient with cancer.