发明名称 |
DEVICES, COMPOSITIONS AND METHODS FOR IMAGING WITH RAMAN SCATTERING |
摘要 |
Methods, systems and computer-accessible medium for imaging a living cell or a living organism with bond-edited compounds using stimulated Raman scattering are disclosed. The method comprises the steps of introducing one or more bond-edited compounds into a live cell or a living organism, and detecting a vibrational tag in the cell or organism with stimulated Raman scattering. Also disclosed are methods for detecting a disease condition in a subject, methods for monitoring treatment for a disease condition, methods for screening an agent, methods for tracing a cellular process in a live cell using bond-edited compounds in combination with stimulated Raman scattering. Also disclosed are a composition for labeling a target cell with at least one bond-edited compound and devices for imaging bond-edited compounds by stimulated Raman scattering. |
申请公布号 |
US2016243261(A1) |
申请公布日期 |
2016.08.25 |
申请号 |
US201514974992 |
申请日期 |
2015.12.18 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK |
发明人 |
MIN WEI;WEI LU;CHEN ZHIXING;HU FANGHAO;SHEN YIHUI |
分类号 |
A61K49/00;G01N33/58;G01N33/569 |
主分类号 |
A61K49/00 |
代理机构 |
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代理人 |
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主权项 |
1. A method for imaging a living cell or a living organism, comprising:
introducing an effective amount of a bond-edited compound into a live cell or a living organism, wherein the bond-edited compound comprises a vibrational tag; and detecting the vibrational tag in the cell or the organism with stimulated Raman scattering (SRS) imaging. |
地址 |
New York NY US |