| 发明名称 |
LIQUID INSULIN FORMULATIONS AND METHODS RELATING THERETO |
| 摘要 |
Liquid formulations of insulin that contain physically and chemically stable insulin but do not contain preservatives or stabilizers are provided. The formulations also lack surfactants. The formulations are useful for various modes of delivery including pulmonary delivery. |
| 申请公布号 |
US2016243199(A1) |
申请公布日期 |
2016.08.25 |
| 申请号 |
US201514977137 |
申请日期 |
2015.12.21 |
| 申请人 |
Dance BioPharm, Inc. |
发明人 |
Bueche Blaine;Kuo Mei-Chang;Patton John;Sander Matthew |
| 分类号 |
A61K38/28;A61K9/00 |
主分类号 |
A61K38/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An insulin formulation, comprising:
insulin at a minimal concentration of 1-13 mM; a salt at a concentration of 50-150 mM; a pH buffering agent at a concentration of 3-24 mM; zinc at a ratio of 1.9-2.7 zinc ions per insulin hexamer; and a pH in the range of 7.2 to 8.0, wherein the formulation does not contain preservatives or stabilizers. |
| 地址 |
Brisbane CA US |
