COMPOSITIONS AND METHODS COMPRISING A DEFINED MICROBIOME AND METHODS OF USE THEREOF

摘要

The invention features the use of a defined microbial consortia for the replacement of a gut microbiome associated with disease. In particular, the invention provides for the treatment of hyperammonemia, Clostridium difficile colitis, hepatic encephalopathy associated with cirrhosis, and inflammatory bowel disease.

主权项

1. A method for altering gut microbiota to reduce urease gene content or activity via reducing or eliminating urease producing bacteria from the gut in order to reduce ammonia production therefrom, in a subject in need thereof, the method comprising; administering to the subject a composition comprising a defined microbial consortia of bacteria having minimal urease activity or no urease gene content, under conditions wherein said bacteria colonize the gut, thereby reducing urease gene content, or activity or both in gut microbiota and ammonia production in the gut of the subject.