ANTIMICROBIAL SUBSTITUTED THIAZOLES AND METHODS OF USE

摘要

Disclosed are compositions having activity against MRSA and/or VRSA, and methods of using the compositions to treat microbial infections.

主权项

1. A method of treating a microbial infection in a subject comprising administering to the subject a pharmaceutical composition in an amount effective to treat the infection, the pharmaceutical composition comprising a compound having the chemical structure: wherein Z consists of a cationic moiety and optionally a linker through which the cationic moiety is attached to the thiazole ring, Y is a lipophilic moiety that is not an alkyl and not an alkoxy, and R consists of H or any suitable substituent, wherein the compound has antimicrobial activity, and wherein the compound does not substantially disrupt bacterial cell membranes.