| 摘要 |
Amino-substituted-malonato platinum(II) complexes represented by the general formula L2PtII(OCO)2CH-NH2 wherein L and L2 are monodentate and bidentate aliphatic amine ligands respectively. Typical examples of L and L2 are: NH3, ethylendiamine, 1,2-diaminocyclohexane, ethylenimine, and cyclopropyl-, cyclobutyl-, cyclopentyl-, cyclohexyl-, isopropyl-, n-propyl-amine. The compounds are characterized by high antitumor activity in mice, chemical stability and solubility in aqueous fluids for i.v. administration. The invention provides also a preferred method for their preparation.
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