发明名称 |
Production of erythropoietin by endogenous gene activation |
摘要 |
The invention concerns human cells which, owing to the activation of the endogenous human erythropoietin gene, can produce erythropoietin (EPO) in sufficient quantities and degree of purity to allow human EPO to be economically produced as a pharmaceutical preparation. The invention also concerns a process for producing such human EPO-producing cells, DNA-constructs for activating the endogenous EPO gene in human cells and a process for the large-scale production of EPO in human cells. |
申请公布号 |
AU8978698(A) |
申请公布日期 |
1999.02.16 |
申请号 |
AU19980089786 |
申请日期 |
1998.07.22 |
申请人 |
BOEHRINGER MANNHEIM G.M.B.H. |
发明人 |
ANNE STERN;MICHAEL BRANDT;KONRAD HONOLD;JOHANNES AUER;HANS KOLL |
分类号 |
C12N15/09;A61K38/00;A61K38/18;A61K38/22;A61P43/00;C07K1/16;C07K1/20;C07K1/22;C07K14/505;C12N5/10;C12N15/10;C12N15/12;C12N15/62;C12N15/63;C12N15/85;C12N15/90;C12P21/02 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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