发明名称 |
INDOLE-3-PROPIONIC ACIDS, SALTS AND ESTERS THEREOF USED AS MEDICAMENTS |
摘要 |
The cytotoxic effects of amyloid beta protein on cells are prevented by contacting the cells with an effective amount of an indole-3-propionic acid or a salt or ester thereof. Furthermore, a fibrillogenic disease can be treated in a human subject by administering to the human subject an amount of an indole-3-propionic acid or a salt or ester thereof effective to prevent or reverse fibrillogenesis. Oxidation in a biological sample can be decreased by contacting the biological sample with an effective amount of an indole-3-propionic acid or a salt or ester thereof. Additionally, diseases or other conditions where free radicals and/or oxidative stress play a role can be treated by administering an effective amount of an indole-3-propionic acid or a salt or ester thereof.
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申请公布号 |
WO9942102(A1) |
申请公布日期 |
1999.08.26 |
申请号 |
WO1999US03906 |
申请日期 |
1999.02.23 |
申请人 |
SOUTH ALABAMA MEDICAL SCIENCE FOUNDATION;NEW YORK UNIVERSITY |
发明人 |
PAPPOLLA, MIGUEL, A. |
分类号 |
A61K31/403;A61K31/404;A61K31/405;A61P9/10;A61P11/00;A61P25/00;A61P25/16;A61P25/28;A61P35/00;A61P43/00;C07D209/18;(IPC1-7):A61K31/405 |
主分类号 |
A61K31/403 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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