发明名称 |
METHOD OF PREPARING DILTHIAZEM |
摘要 |
FIELD: chemical industry. SUBSTANCE: dilthiazem is prepared by reacting cis -(+)-hydroxy-5-[2-(dimethyl-5-(2-(dimethylamino)- ethyl]-2,3-dihydro-2-(4-methoxyphenyl)benzothiazepin- 4(5H)-one prepared by reaction of cis-(+)-3-hydroxy-2-(4- methoxyphenyl)benzothiazepine-4(5H)-one with 2- chloroethyl dimethylamine in mixture of toluene and N- methylpyrrolidin-2-one in the presence of finely ground sodium carbonate and acetic anhydride. EFFECT: simplified process and increased yield of the desired product. 5 cl, 2 ex
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申请公布号 |
RU2139853(C1) |
申请公布日期 |
1999.10.20 |
申请号 |
RU19960102864 |
申请日期 |
1996.02.16 |
申请人 |
ORION-IKHTJUMJA OJ FERMION |
发明人 |
MARTTI KHJUTENEN |
分类号 |
C07C281/10;A61K31/55;A61K31/554;A61P9/00;A61P9/06;A61P9/14;C07D281/10;(IPC1-7):C07C281/10 |
主分类号 |
C07C281/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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