The present invention is directed to novel recombinant nucleic acids for introducing yeast chromosomal elements into the genomes of bacteria. The invention provides methods to convert the modified bacterial genomes into artificial yeast chromosomes by fusing the bacteria with yeast that linearize the modified bacterial genomes, to produce artificial chromosomes.
申请公布号
WO0006715(A1)
申请公布日期
2000.02.10
申请号
WO1999US16297
申请日期
1999.07.26
申请人
GENOTYPES INC.;HITZEMAN, RONALD;CHISOLM, GEORGE, E., IV