发明名称 |
pró-farmácos de conjugado baseado em atifungicos e antibacterianos |
摘要 |
The invention provides conjugate-based antifungal or antibacterial prodrugs formed by coupling at least one anti-fungal agent or antibacterial agent with at least one linker and/or carrier. The prodrugs are of formula: (i) (AFA)m-X-(L)n; (ii) [(AFA)m′-X]p-L; (iii) AFA-[X-(L)n′]q; or (iv) (AFA)m″-X, wherein: AFA is an antifungal agent or an antibacterial agent; L is a carrier; X is a linker; m ranges from 1 to 10; n ranges from 2 to 10; m′ is 1 to 10; p is 1 to 10; n′ is 1 to 10; and q is 1 to 10, provided that q′ and n are not both 1; and m″ is 1 to 10. The invention also provides nanoparticles comprising the conjugate-based prodrugs. Additionally, the invention also provides non-conjugated antifungal and antibacterial agents in the form of nanoparticles. |
申请公布号 |
BR112013033239(A2) |
申请公布日期 |
2016.09.06 |
申请号 |
BR20131133239 |
申请日期 |
2012.06.22 |
申请人 |
VYOME BIOSCIENCES |
发明人 |
ABHIJIT S BAPAT;GAUTHAMI MAHESH;RAJESH S. GOKHALE;SAYALI S. SHAH;SHILADITYA SENGUPTA;SUDHANAND PRASAD |
分类号 |
A61K47/48;A61K8/37;A61P17/10;A61P31/04;A61Q5/02;A61Q17/00 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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