发明名称 |
INHIBITORS AND THEIR USES |
摘要 |
The present invention relates to inhibitors of PPP1 R15A and PPP1 R15B and their use in therapy, particularly in the treatment of a disease state alleviated by the inhibition of PPP1 R15A and PPP1 R15B, for example a disorder associated with accumulation of misfolded proteins or proteostatsis disorder. Compounds of the invention include compounds having the formula IA or a pharmaceutically acceptable salt thereof, wherein R1a, R3a, R5a, Xa and Ya are as defined herein. |
申请公布号 |
WO2016162689(A1) |
申请公布日期 |
2016.10.13 |
申请号 |
WO2016GB50991 |
申请日期 |
2016.04.08 |
申请人 |
MEDICAL RESEARCH COUNCIL |
发明人 |
BERTOLOTTI, Anne;DAS, Indrajit;KRZYZOSIAK, Agnieszka;ROUSSEAU, Adrien;SCHNEIDER, Kim;SIGURDARDOTTIR, Anna Gudny |
分类号 |
A61K31/155;C07C281/18;C07D253/00 |
主分类号 |
A61K31/155 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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