DENDRIMER COMPOSITIONS, METHODS OF SYNTHESIS, AND USES THEREOF

摘要

The disclosure relates to novel dendrimer conjugates and the methods of synthesizing the same, as well as systems and methods utilizing the dendrimer conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease diagnosis and/or therapy, etc.))).

主权项

1. A dendrimer conjugate comprising a G2 to G10 polylysine dendrimer conjugated with a nitroimidazole ligand/metal complex having the following structure: wherein n is an integer from 0 to 8 inclusive; R1, R2 and R3 independently represent H, NO2 or methyl; R′1 and R′2 independently represent H, OH, methyl, ethyl or propyl; X1, X2 and X3 independently represent ø, CO or H2O as allowed by the valence of metal M; and M represents a radioactive or non radioactive (cold) isotope of a transition metal selected from Y, Zr, Nb, Mo, Tc, Ru, Rh, Pd, Ag, Cd, Re, In or Sn.