发明名称 |
IMPROVED MENIGOCOCCAL POLYSACCHARIDE CONJUGATE VACCINE |
摘要 |
Neisseria meningitidis group B polysaccharide (GBMP) modified by having sialic acid residue N-acetyl groups replaced by N-acyl groups exhibits enhanced immuno response thereto. In addition, induction of antibodies which cross-react with unmodified group B meningococcal and E. coli K1 capsular polysaccharide and other tissue cells having a common epitope is minimized. Conjugation of the modified polysaccharides with a physiologically acceptable protein such as tetanus toxoid induces the production of specific protective antibodies with negligible levels of GBMP-cross reactive antibodies, to thereby afford protection against infections caused by group B meningococci and E. coli K1. |
申请公布号 |
ZA9010065(B) |
申请公布日期 |
1992.02.26 |
申请号 |
ZA19900010065 |
申请日期 |
1990.12.14 |
申请人 |
NATIONAL RESEARCH COUNCIL OF CANADA |
发明人 |
HAROLD J. JENNINGS;FRANCIS MICHON |
分类号 |
A61K39/00;A61K38/00;A61K39/02;A61K39/095;A61K39/108;A61K39/385;A61K39/395;A61P31/04;C07K16/12;C08B37/00;C12P19/04 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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