| 摘要 |
A method of forming hollow, porous elastomeric bodies and hollow, duo-layered elastomeric bodies wherein one layer is porous and contiguous with the other layer which is solid by a) coating a surface of a mandrel with a coating liquid, b) adhering a layer of water-elutable particles onto the coated mandrel surface, c) applying a layer of fluid elastomeric composition to the particle-coated mandrel surface wherein the elastomeric composition is capable of forming a water-insoluble elastomer, d) causing said elastomeric composition to form a cohesive mass while in contact with the particle-coated mandrel surface, e) dissolving said elutable particles from the cohesive mass with a water-based solvent, and f) removing the cohesive mass from the mandrel. The coating liquid comprises water and may also further comprise a wetting agent and/or a sugar. The invention also relates to the method wherein the water-elutable particles are adhered to the mandrel surface by heating the mandrel surface. The method is useful for making prostheses, e.g., mammary prostheses and vascular prostheses. |
