发明名称 |
Direct compression cholestyramine tablet and solvent-free coating thereof |
摘要 |
A directly compressed cholestyramine tablet with a solvent-free coating is disclosed. The inner core of the tablet is made up of cholestyramine agglomerates consisting of numerous small, irregularly-shaped, jagged-edged fragments having relatively few smooth or flat surfaces with a moisture content ranging from about 8 to 14 percent by weight. A process is also disclosed for preparing cholestyramine agglomerates of the invention. The solvent-free coating comprises from about 60 percent to about 95 percent by weight of stearic acid and from about 5 percent to about 40 percent of polyethylene glycol.
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申请公布号 |
US5372823(A) |
申请公布日期 |
1994.12.13 |
申请号 |
US19920965096 |
申请日期 |
1992.10.22 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
BEQUETTE, ROBERT J.;BONENBERGER, BRUCE A.;GALLIAN, CLAUDE E.;RECKELHOFF, JOHN R. |
分类号 |
A61K9/28;A61K9/30;A61K9/42;A61K31/785;(IPC1-7):A61K9/20;A61K9/16 |
主分类号 |
A61K9/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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