PHARMACEUTICAL COMPOSITION CONTAINING (S)-(-)-2-(4-ISOBUTYL- -PHENYL)-PROPIONATE SODIUM, METHOD OF SYNTHESIS OF 2-(4- -ISOBUTYLPHENYL)-PROPIONIC ACID SODIUM SALT ENANTIOMER, (S)-(-)-2-(4-ISOBUTYLPHENYL)-PROPIONATE SODIUM DIHYDRATE

摘要

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes tabletted pharmaceutical composition containing (S)-(-)-2-(4-isobutylphenyl)-propionate sodium, its enantiomeric purity is 90%, not less, and a carrier. Composition exhibits improved moldability in lengthy pressing cycles. Invention describes also (S)-(-)-2-(4-isobutylphenyl)-propionate sodium exhibiting enantiomeric purity above 90% and method of its synthesis. Synthesis of (S)-(-)-2-(4-isobutylphenyl)-propionate sodium of increased enantiomeric purity ensures to obtain tabletted pharmaceutical forms based on said. EFFECT: increased purity, improved properties of compositions. 11 cl, 31 ex