发明名称 |
Lipophilic quenching of viral inactivating agents |
摘要 |
Methods and compositions for the inactivation and removal of contaminants of a biological composition are disclosed. The methods include the steps of: (a) contacting the biological composition with an inactivating agent including an aziridino moiety, such as ethyleneimine, an oligomer of ethyleneimine, or a haloderivative salt of either ethyleneimine or an oligomer of ethyleneimine, where a portion of the agent reacts with and inactivates the contaminant, and a portion of the agent remains unreacted; (b) contacting the product of step (a) with a lipophilic quenching agent including at least one quenching moiety attached to a lipophilic moiety, under conditions and for a time sufficient to allow the unreacted agent to bond covalently to the quenching moiety; and (c) separating the lipophilic quenching agent and the quenched inactivating agent from the biological composition.
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申请公布号 |
US6150109(A) |
申请公布日期 |
2000.11.21 |
申请号 |
US19990237136 |
申请日期 |
1999.01.25 |
申请人 |
V. I. TECHNOLOGIES, INC. |
发明人 |
EDSON, CLARK M.;PURMAL, ANDREI A.;ACKERMAN, SAMUEL K. |
分类号 |
C12N7/04;A61K35/14;A61K35/20;A61K35/24;A61K35/26;A61K35/50;A61K35/52;A61K38/00;A61P31/12;C07D203/06;C07D203/12;C07F9/165;C07F9/6539;C07K14/47;C12N7/06;C12R1/92;(IPC1-7):C12Q1/68;C07H21/04;A61K48/00 |
主分类号 |
C12N7/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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