Ethynyl derivatives

摘要

The present invention relates to ethynyl derivatives of formula I;
wherein
Y is N or CHR1 is fluoro or chloro

or to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof.
;It has now surprisingly been found that the compounds of general formula I are metabotropic glutamate receptor antagonists (negative allosteric modulators) for use in the treatment of anxiety and pain, depression, Fragile-X syndrom, autism spectrum disorders, Parkinson's disease, and gastroesophageal reflux disease (GERD).

主权项

1. A compound of formula Iwherein
Y is N or CH; R1 is fluoro or chloro;or a pharmaceutically acceptable acid addition salt, racemic mixture, enantiomer, optical isomer or stereoisomer thereof.