ANTAGONIST ANTI-IL-7 RECEPTOR ANTIBODIES AND METHODS

摘要

The present invention provides antagonizing antibodies that bind to interleukin-7 receptor (IL-7R). The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acids. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof for the treatment and/or prevention of type 2 diabetes and immunological disorders, including type 1 diabetes, multiple sclerosis, rheumatoid arthritis, graft-versus-host disease, and lupus.

主权项

1. An isolated interleukin-7 receptor (IL-7R) antibody which specifically binds to interleukin-7 receptor alpha (IL-7Rα) and comprises an antigen binding region that cross-competes with a monoclonal antibody selected from the group consisting of P3A9, P4B3, P2D2, P2E11, HAL403a, HAL403b, C1GM and C2M3, for binding to IL-7Rα.